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MySpace Profile: axin
male, 29, Türkei
Interests
AXIN Shapes Tankyrase ARChitecture: Structure - Cell Press
www.cell.com
The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat ...
The links between axin and carcinogenesis - Journal of Clinical ...
jcp.bmj.com
Thus, axin can bind to either GSK3 or MEKK1 and form distinct complexes with opposing effects on apoptosis. Although axin can be ''switched'' to activate the SAPK/JNK pathway instead of Wnt signalling, it is still capable of downregulating b catenin.44 Axin domains essential for Wnt signalling activation ...
SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for...
www.jbc.org
... adding to the emerging picture that Axin can be dedicated to at least two independent pathways, the Wnt signaling and the JNK MAP kinase pathway.
lastFM: Can Were (Released Track) — Jan Axin | Last.fm
Watch the video, get the download or listen to Jan Axin – Can Were (Released Track) for free. Discover more music, gig and concert tickets, videos, lyrics, free ...
Books & Literature
APC Proteins - Page 2 - Google Books Result
books.google.co.jp
While the Axin/APC scaffolds are required for efficient phosphorylation of β- catenin by GSK3β, this reaction is also greatly enhanced by prior phosphorylation of β-catenin by CKIα or CKIε Consistent with this, reduction of CKI activity results in elevated β-catenin levels and signaling A tagged form of Axin can pull ...
Epstein's Inborn Errors of Development: The Molecular Basis of ...
books.google.co.jp
Conversely, dephosphorylation of Axin by a different serine/threonine phosphatase, PP1, promotes dissociation of the β-catenin destruction complex ( Luo et al., 2007). The C-terminal DIX domain of Axin can bind Dvl (Kishida et al., 1999b), an interaction that promotes dissociation of Axin from the destruction complex and its ...
Physiology of the Gastrointestinal Tract
books.google.co.jp
By bringing both substrate (β-catenin) and enzymatic activities (GSK-3β and CK1α) in close vicinity, Axin can increase the rate of phosphorylation of β-catenin enormously, by some estimates more than 24,000-fold (63,71). In addition to this scaffolding function, Axin also seems toplay a role in supporting the nuclear export ...
Physiology of the Gastrointestinal Tract, Two Volume Set
books.google.co.jp
... disheveled.96 By bringing both substrate (β-catenin) and enzymatic activities ( GSK3β and CK1α) in close vicinity, Axin can increase the rate of phosphorylation of β-catenin enormously, by some estimates more than 24,000-fold.64,71 Experimental data and mathematical models have suggested that Axin protein seems to ...
Music
Jan Axin - Can Were - Listen on Deezer
www.deezer.com
Length : 05:12. This track is on the 3 following albums: Evînên Şikestî · Jan Axin · Evînên Sikestî · Jan Axin · Kayıp Zamanlarda Yolculuk · Hekim Hekimoğlu.
Related Documents
Abnormal β-Catenin and Reduced Axin Expression Are CiteSeerX
citeseerx.ist.psu.edu
pathway, axin can inhibit the proliferation of tumor cells. Our study showed that of 100 NSCLC samples, more than half had reduced axin expression and that preserved axin expression was significantly higher in well- or moderately differentiated tumors than in poorly differentiated tumors. Reduced axin expression was ...
2.2 Canonical Wnt signaling - IS MU - Masarykova univerzita
is.muni.cz
required for Axin oligomerization and Axin can serve as scaffolding protein, anchoring several other molecules to create a molecular complex with the mass above 1MDa (Kishida et al., 1999) Glycogen-synthase kinase-3β (GSK-3β). GSK-3β is a serine/threonine kinase, which phosphorylates and ...
Notch modulates Wnt signalling by associating with Armadillo/β ...
genetics.med.harvard.edu
that Axin can regulate the activity of Armadillo/β-catenin in a. Shaggy/GSK3β- independent manner (Tolwinski et al., 2003;. Tolwinski and Wieschaus, 2004b). This has led to the. Fig. 7. Armadillo associates with Notch in Drosophila embryos . Notch protein was immunoprecipitated from wild-type embryos and the presence of ...
Unravelling the molecular mechanisms of the canonical Wnt signalling ...
dspace.library.uu.nl
However, live cell imaging experiments suggested that while APC and Axin can enrich β-catenin in the cytoplasm, Tcf and β-catenin co-activators such as BCL9 and Pygopus can increase nuclear β-catenin, thus indicating that they likely only participate in β-catenin cytoplasmic or nuclear retention rather than shuttling92.
Scientific Publications
AXIN1 - an overview | ScienceDirect Topics
www.sciencedirect.com
AXIN1. Axin is an ... in bone density stemming from an increase in osteoblast differentiation and a decrease in osteoclast differentiation. 50 Axin can also ...
The trimeric G protein Go inflicts a double impact on axin in KOPS
kops.uni-konstanz.de
The inhibitory activity of Axin can be suppressed by co-expression of the GTP- binding protein Gαo, leading to a partial rescue in wing development (yellow). Gαo physically binds the RGS domain of Axin and recruits Axin it to the plasma membrane, antagonizing the Axin-based destruction complex. Subject (DDC):,
AXIN Shapes Tankyrase ARChitecture - Science Direct
www.sciencedirect.com
The poly(ADP-ribose)polymerase (PARP) Tankyrase uses ankyrin repeat modules to capture substrates via Tankyrase-binding peptide motifs. In this issue of Structure, Eisemann et al. (2016) describe how the signaling protein AXIN can access and conformationally adapt the multivalent ankyrin repeat ...
Overexpression of axin downregulates TCF-4 and inhibits the NCBI
www.ncbi.nlm.nih.gov
CONCLUSION: These results suggest that reduced expression of axin or augmented expression of TCF-4 is associated with the malignant behavior of lung cancers. Overexpression of axin can downregulate expression of TCF-4 and can inhibit the ability of lung cancer cells to proliferate and invade.
Publications
Differential Molecular Assemblies Underlie the Dual Function of Core
core.ac.uk
In either case, Axin can still function to keep free ß-catenin levels in check by degradation or sequestration of the cytosolic portion of ß-catenin. The role of GSK -3ß as a down-regulator of Wnt signaling has been extensively investigated. In Xenopus, dorsoventral axis formation established in the early blastula depends on ...
Protein Phosphatase 2A in the Regulation of Wnt Signaling MDPI
www.mdpi.com
Axin phosphorylation within the β-catenin binding domain increases binding to β- catenin, stabilizing Axin and increasing β-catenin degradation [22]. Using a combination of yeast-two hybrid screening and co-immunoprecipitation,. Hsu et al. showed that Axin can bind directly to the PP2Ac catalytic subunit ...
Overexpression of Axin Downregulates TCF-4 and …
link.springer.com
SpringerLink. Search Overexpression of Axin Downregulates TCF-4 and Inhibits the ... Overexpression of axin can downregulate expression of TCF-4 and can ...
Domains of Axin Involved in Protein–Protein BioMedSearch
www.biomedsearch.com
aa of Axin can mediate multimerization, the strong domi- nant negative forms of Axin may act by binding to endoge-. Figure 7. Electron microscopic localization of Myc–. Axin. (A–C) EM localization of FL Myc–Axin by on-section staining on Lowycryl sections. (A) Low magnification view of an Axin-positive ...
Video & Audio
Can Were - Jan Axin & Jan Axîn & Ares Müzik | Shazam
www.shazam.com
Can Were. Jan Axin & Jan Axîn & Ares Müzik. 57 Shazams. jan-axin. Jan Axin Shazams. apple · itunes · google · amazon. Music Videos. Jan Axin - Can Were. 4,048 views. Can Were. 0 views. Jan Axin - Gulevin. 2,952 views. Top Songs By Jan Axin Keçikê Bimeş - Jan Axin · Keçikê Bimeş · Jan Axin
Jan Axin - Can Were sur Orange Vidéos - Video-streaming-Orange
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▶ 5:12Jan Axin - Can Were.
Jan Axin - Can Were - YouTube
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Apr 19, · Jan Axin - Can Were. Category Music; License Standard YouTube License; Music "Can Were" by Jan Axin Listen ad-free with YouTube Red; Show more Show less.
jan axîn - bajar - YouTube
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Feb 08, · Jan Axin - Can Were - Duration: 5:12. Ares Müzik 3,833 views. 5:12. Dil Perîşanim - Mihemed Şêxo - Duration: 6:23. kurdil 1,673,864 views. 6:23.
Reports & Statements
Twitter Posts: Summer Glory Lopez (summer_asian)
People always axin' "CAN U SEE ME?!" #CauseImAsian @HassanaTheAsian
Twitter Posts: Alex M. Pruteanu (lx69)
@michaelbcain i l ike that guy aXin: 'can I borrow a feelin'?' with that crooked f-ed up eye.
Twitter Posts: axin can on Twitter: "@cghnbfgn @ZbekNder @ferhatttunc ker diya ...
axin can · @axin_ce. gider-gelir 'kendine' çarpar!!! kiblem Çocuk YÜREĞIDİR... Şervan Dara'nın annesiyim... Bu kadarim... Joined April Tweets. © Twitter; About · Help Center · Terms · Privacy policy · Cookies · Ads info. Dismiss. Close. Previous. Next. Close. Go to a person's profile. In this conversation. Verified ...
Sernix Test Server [Axin's] :: Sernix Coop Insurgency - Steam Community
steamcommunity.com
Oct 29, @ 6:18am. Axin's access to that server was revoked for engaging in behavior unbecoming of an admin...to put it lightly. Edit: I should add that Axin can reach out to Daimyo at any time regarding this issue. To my knowledge, Axin has not yet done so. Last edited by Whiskey; Oct 29, @ 6: ...
Miscellaneous
WO A1 - Google
www.google.com
PLoS Biol 2003, 1 , E10) and increased expression of Axin can enhance β- catenin degradation in cell lines expressing truncated APC (Behrens, J. et al. Science 1998, 280, ; Kishida, M. et al. Oncogene 1999, 18, ; and Hart, M. J., et al. Curr Biol 1998, 8, ). Thus, it is likely that Axin protein levels need to ...
CN A - Primer-probe combination for detecting expression ...
patents.google.com
The invention relates to a primer-probe combination for detecting the expression level of human axin2 genes.The primer-probe combination has the advantages that specific primers and probes are designed aiming at the mRNA of human axin genes, and the expression level of the axin genes can be detected through a ...
axin can | LinkedIn
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View axin can’s professional profile on LinkedIn. LinkedIn is the world's largest business network, helping professionals like axin can discover inside connections ...
The RGS domain of Axin can directly interact with but does not change...
www.researchgate.net
Figure 2: The RGS domain of Axin can directly interact with but does not change activity of Gαo. A: Pull-down with the RGS domain of Axin immobilized on a matrix (RGS) but not with the control matrix (MBP) precipitates equally the recombinant myristoylated Gαo and Gαo[GTP] proteins, as detected by anti-Gαo Western blot.
Jan Axin - Can Were | Yabancı Şarkı Sözleri, Şarkı Çevirileri, Şarkı ...
sarkiceviri.gen.tr
Jan Axin Can Were Türkçe ÇevirisiCan Were Tu were, can were An jî Ez werim. Çi qas giriyam, çav riziyan Çi qas êşiyam, dil riziya Çi qas geriyam, ling rizi.
Jan Axin - Can Were Çevirisi | SozuSozleri.com
sozusozleri.com
Jan Axin - Can Were, Şarkı sözü çevirisi, Can Were Tu were, can were An jî Ez werim. Çi qas giriyam, çav riziyan Çi qas êşiyam, dil riziya Çi , Jan Axin çeviri.
Jan Axin - Can Were Şarkı Çevirisi
ceviri.alternatifim.com
Jan Axin Şarkı Çevirileri - Can Were : Can Were Tu were, can were An jî Ez werim. Çi qas giriyam, çav riziyan Çi qas êşiyam, dil riziya Çi qas...
Tissue-specific roles of Axin2 in the inhibition and ...
www.pnas.org
Axin2 null mutants are viable ... Our results provide in vivo support for studies that suggested that Axin can play a positive role in canonical Wnt signaling ...
1 The effect of Wnt signaling on the localization, molecular bioRxiv
www.biorxiv.org
Previous experiments in embryos and imaginal discs provide strong support for this, as over-expressing Axin can shut down Wnt signaling. They also suggest this only occurs when Axin levels exceed a specific threshold. Our knowledge of the relative levels of APC2 versus Axin in the Drosophila embryonic ...
AM09377PU-S – Axin 1(AXIN1) Mouse Monoclonal Antibody [Clone ...
www.origene.com
Axin1 is characterized to be a tumor suppressor and numerous gene mutations have been identified throughout Axin1 from a number of different cancers. Axin can identify in a mouse mutant strain, created by random integration of a transgene. Also, Axin1 plays an important role in the formation of the embryonic neural axis.
APC is crucial for Axin complex assembly | Open Biology
rsob.royalsocietypublishing.org
Likewise, overexpression of Drosophila Axin reverses the 'naked' embryonic phenotype caused by an apc point-mutation (called N175K) towards normal [18]. High levels of overexpressed Axin can thus compensate for dysfunctional APC in flies and human cells, suggesting that APC acts through Axin by ...
AXIN1 - axin 1 - Ihop-net.org
www.ihop-net.org
In addition, Dvl and Axin can activate the mitogen-activated protein kinase JNK via distinct mechanisms, through interaction with MEKK1/4 and Rac GTPase, respectively. Paper Taken together, these results suggest that GSK- 3beta-dependent phosphorylation of APC can be modulated by beta-catenin and PP2A ...
An Updated Overview on Wnt Signaling Pathways - Circulation ...
circres.ahajournals.org
zled, dishevelled, and axin can directly interact with some. G-protein subunits.80, 81 Also, genetic evidence argues for a requirement of G proteins in Wnt signaling Dkk1: Beyond a Wnt Inhibitor. Dkk1 is among the best-characterized inhibitors of the ca- nonical Wnt pathway. Dkk1 itself is a target gene of ...
Apc2 Point Loc_4 - G3: Genes | Genomes | Genetics
www.g3journal.org
Ank2 seems to act independently from other players, except its membrane partner, Neuroglian (Nrg). Rac1 likely acts through Arp2/3 to generate branched actin to help recruit Apc2-GFP. Axin can function in a variety of wnt signaling pathways, one of which includes heterotrimeric G proteins and Frizzleds.
Axin Contains Three Separable Domains That Confer Intramolecular ...
dspace.xmu.edu.cn
Abstract. Axin is a major scaffold protein, interacting with diverse molecules involved in a number of signaling pathways. Axin can undergo dimer/ oligomerization via its DIX domain. Here we show that whereas deletion of the DIX domain at the C terminus rendered Axin incapable of forming dimer, a larger ...
Axin stimulates p53 functions by activation of HIPK2 kinase through ...
emboj.embopress.org
(A) Axin can activate p53 transactivation in a dose‐dependent manner. Axin (0, 0.5, 1.0, 2.0, and 3.0 μg) and 0.5 μg of the PathDetect p53‐Luc reporter ( Stratagene) were cotransfected in HEK 293 cells to test the effect of Axin on p53‐ dependent transcriptional activity. (B) Axin mutants defective in p
Axin1 Antibody|Axin-1, Mouse Anti Human - Novatein Biosciences
www.novateinbio.com
Axin can be identified in a mouse mutant strain, created by random integration of a transgene. Mutations in the AXIN1 gene are linked to hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Synonyms. Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN, MGC
Axin: A Master Scaffold for Multiple Signaling Pathways
www.karger.com
sistently, Dvl heterodimeric interaction with Axin can also abolish JNK activation by Axin. Axin with the. MEKK1-binding domain deleted could prevent wild-type. Axin from activating JNK, indicating that Axin requires. MEKK1 to assume a dimeric configuration which may be an important feature of MEKK activation in the Axin/.
DIXDC1 - Dixin - Function - neXtProt
www.nextprot.org
In addition, Dvl and Axin can activate the mitogen-activated protein kinase JNK via distinct mechanisms, through interaction with MEKK1/4 and Rac GTPase, respectively. Axin utilizes two distinct domains for interaction with MEKK1 and MEKK4. JNK activation by Axin is regulated by several factors in the Wnt pathway , ...
Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell ...
cancerres.aacrjournals.org
A, Daxx and Axin can cooperatively stimulate p53-Luc reporter activity (left) and the siRNA against Axin diminished Daxx-induced p53 transactivation (right) cells were transfected as indicated and cell lysates were measured for luciferase activity. B, both Daxx and Axin could enhance the transcriptional ...
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